This report presents a multidisciplinary analysis of COVID-19 and its impact on Nepal’s foreign affairs, economy, governance, and society. It examines how the pandemic disrupted global and regional systems, altered diplomatic practices, and intensified challenges for developing countries like Nepal. The study highlights key issues including economic slowdown, migration, public health pressures, and shifts toward digitalization and virtual diplomacy. It also explores emerging opportunities in green economy, governance reform, and policy innovation. The report emphasizes the need for evidence-based, coordinated, and adaptive policy responses to strengthen resilience and guide Nepal’s foreign and domestic policy in a rapidly changing global context.